Bio-Active Compounds Discovery Research Unit

Unit Leader

Nobumoto Watanabe

D.Sci.

Nobumoto Watanabe

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1987
D.Sci., University of Tokyo
1987
Postdoctoral Researcher, Molecular Oncology Laboratory, RIKEN
1989
Research Scientist, Gene Bank, RIKEN
1992
Research Associate, Salk Institute, USA
2001
Senior Research Scientist, Antibiotics Laboratory, RIKEN
2006
Visiting Professor, Universiti Sains Malaysia: USM, Malaysia (-current)
2008
Senior Research Scientist, Chemical Library Validation Team, RIKEN
2009
Team Head, Chemical Library Validation Team, RIKEN
2013
Unit Leader, Bio-Active Compounds Discovery Research Unit, RIKEN Center for Sustainable Resource Science (-current)

Contact

nwatanab

Bio-Active Compounds Discovery Research Unit,
Chemical Biology Research Group,
RIKEN Center for Sustainable Resource Science

Chemical Biology Building,
2-1 Hirosawa, Wako, Saitama 351-0198 Japan
Access to Wako

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Outline

Bio-Active Compounds Discovery Research Unit
As the research platform for the sustainable resources and their application, we are developing the platforms for the discovery and validation of useful bio-active compounds. After the development and refinement of these platforms, bioactive compounds useful for the improvement of photosynthesis efficiency, N2 fixation, denitrification and recovery of rare metals will be identified. We will validate the bioactivity of RIKEN NPDepo chemical library compounds and develop and refine the detection system of the phosphorylation dependent protein-protein interaction. The chemical array systems for the discovery of novel bioactive compounds are also being improved.

Subjects

  1. Construction of the screening system for bio-active compounds with novel molecular targets
  2. Refinement of the chemical array system
  3. Analysis of the mechanisms behind the activities of compounds with novel biological activity
  4. Mining and functional analysis of novel molecular targets
Discovery of Bio-Active Compounds by Chemical Array
High throughput screening system for inhibitors of protein-protein intreaction