Bioprobe Application Research Unit

Unit Leader

Nobumoto Watanabe

D.Sci.

Nobumoto Watanabe

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1987
D.Sci., University of Tokyo
1987
Postdoctoral Researcher, Molecular Oncology Laboratory, RIKEN
1989
Research Scientist, Gene Bank, RIKEN
1992
Research Associate, Salk Institute, USA
2001
Senior Research Scientist, Antibiotics Laboratory, RIKEN
2006
Visiting Professor, Universiti Sains Malaysia: USM, Malaysia (-current)
2008
Senior Research Scientist, Chemical Library Validation Team, RIKEN
2009
Team Head, Chemical Library Validation Team, RIKEN
2013
Unit Leader, Bio-Active Compounds Discovery Research Unit, RIKEN Center for Sustainable Resource Science (-current)
2017
Unit Leader, Bioprobe Application Research Unit, RIKEN-Max Planck Joint Research Division for Systems Chemical Biology, RIKEN Center for Sustainable Resource Science (-current)

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nwatanab

Bioprobe Application Research Unit,
RIKEN-Max Planck Joint Research Division for Systems Chemical Biology,
RIKEN Center for Sustainable Resource Science

Chemical Biology Building,
2-1 Hirosawa, Wako, Saitama 351-0198 Japan
Access to Wako

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Outline

In collaboration with a group of Max Planck Institute (MPI) of Molecular Physiology (group of Prof. Herbert Waldmann), we study the cell cycle control through the identification of small molecule inhibitors of the proteins that have an important role for the progression of cell division. We propose the collaboration of these two groups by taking the merits of both different approaches by frequently exchanging materials, technologies and information. For example, after sending compounds of RIKEN NPDepo chemical library to MPI, the MPI group will screen for compounds that arrest cell division with interesting phenotypes. Then we will analyze the mechanism of action of the compounds by identifying the target proteins of the compounds. In the opposite way, MPI group will provide their compounds for the screening by the high throughput system of us. The isolated interesting compounds will be deeply analyzed by the MPI cell biology group.

Subjects

  1. Screening for small compounds with effects on cell growth and analyses of their mechanism of action
Usefulness of compounds that specifically target cancer stem cells