Chemical Biology Research Group

Group Director

Hiroyuki Osada

D.Agr.

Hiroyuki Osada

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1983
D.Agr., University of Tokyo
1983
Research Scientist, Antibiotics Laboratory, RIKEN
1992
Chief Scientist, Antibiotics Laboratory, RIKEN
2008
Director, Chemical Biology Department, RIKEN
2009
Laboratory Director, Chemical Biology Core Facility, RIKEN
2011
Director, RIKEN-Max Planck Joint Research Center, RIKEN (-current)
2011
Team Leader, Bioprobe Application Team, RIKEN
2011
Team Head, RIKEN-KRIBB Joint Research Team, RIKEN
2011
Team Head, RIKEN-USM Joint Research Team, RIKEN
2013
Deputy Director, RIKEN Center for Sustainable Resource Science
2013
Group Director, Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science (-current)
2013
Unit Leader, Chemical Resource Development Research Unit, RIKEN Center for Sustainable Resource Science (-current)
2015
Division Director, Technology Platform Division, RIKEN Center for Sustainable Resource Science
2016
Unit Leader, Chemical Bank Unit for Drug Discovery Platform, RIKEN Center for Sustainable Resource Science
2018
Unit Leader, Drug Discovery Chemical Bank Unit, RIKEN Center for Sustainable Resource Science (-current)

Contact

cb-secretary[a]ml.riken.jp

Chemical Biology Research Group,
RIKEN Center for Sustainable Resource Science

Chemical Biology Building,
2-1 Hirosawa, Wako, Saitama 351-0198 Japan
Access to Wako

Related links

Outline

Chemical Biology Research Group
In order to promote research in chemical biology that aims to elucidate biological phenomena using chemical compounds as starting materials, it is important to establish a platform for chemical biology. Our group constructs chemical libraries through the genetic engineering of microorganisms and organic synthesis, as well as databases that describe the chemical and biological information of the libraries. We explore useful bioactive compounds in the chemical library, identify molecular targets of bioactive compounds, and elucidate mechanisms behind the actions of active compounds as well. We continue to maintain this infrastructure for advanced studies of chemical biology and sustainable resource science.

Subjects

  1. Expansion of the database of the chemical bank, “Natural Products Depository (NPDepo)”
  2. Expansion of the chemical library using genetic engineering and synthetic chemistry
  3. Exploration of bioactive small molecules and development of new analytical techniques for target identification
2-dimensional distribution map of metabolites based on their physico-chemical properties; polarity and molecular weight, NPPlot; Natural Products Plot
Target prediction of a small molecule by proteomic profiling using 2D-DIGE (ChemProteoBase profiling)