Chemical Biology Research Group

Group Director

Hiroyuki Osada

D.Agr.

Hiroyuki Osada

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1983
D.Agr., University of Tokyo
1983
Research Scientist, Antibiotics Laboratory, RIKEN
1992
Chief Scientist, Antibiotics Laboratory, RIKEN
2008
Director, Chemical Biology Department, RIKEN
2009
Laboratory Director, Chemical Biology Core Facility, RIKEN
2011
Director, RIKEN-Max Planck Joint Research Center, RIKEN (-current)
2011
Team Leader, Bioprobe Application Team, RIKEN
2011
Team Head, RIKEN-KRIBB Joint Research Team, RIKEN
2011
Team Head, RIKEN-USM Joint Research Team, RIKEN
2013
Deputy Director, RIKEN Center for Sustainable Resource Science (-current)
2013
Group Director, Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science (-current)
2013
Unit Leader, Chemical Resource Development Research Unit, RIKEN Center for Sustainable Resource Science (-current)
2015
Division Director, Technology Platform Division, RIKEN Center for Sustainable Resource Science (-current)
2016
Unit Leader, Chemical Bank Unit for Drug Discovery Platform, RIKEN Center for Sustainable Resource Science (-current)

Contact

hisyo

Chemical Biology Research Group,
RIKEN Center for Sustainable Resource Science

Chemical Biology Building,
2-1 Hirosawa, Wako, Saitama 351-0198 Japan
TEL: +81-(0)48-467-9541
FAX: +81-(0)48-462-4669
Access to Wako

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Outline

To promote “Chemical Biological Research” that aims to elucidate biological phenomena using chemical compounds as starting materials, chemical libraries.

Our group constructs chemical libraries through the genetic engineering of microorganisms and organic synthesis, and databases that describe the chemical and biological information of the libraries.

We explore the useful bioactive compounds in the chemical library and identify the molecular targets of bioactive compounds, and elucidate the mechanisms behind the actions of the active compounds as well.

We continue to maintain the infrastructure for advanced studies of chemical biology and sustainable resource science.

Subjects

  1. Construction of a chemical bank, “Natural Products Depository (NPDepo)”
  2. Expansion of the chemical library using genetic engineering and synthetic chemistry
  3. Exploration of bioactive compounds in the chemical library through high throughput screening systems
  4. Analyses of small molecule-protein interaction and development of the new analytical methods
2-dimensional distribution map of metabolites based on their physico-chemical properties; polarity and molecular weight, NPPlot; Natural Products Plot
Target prediction of a small molecule by proteomic profiling using 2D-DIGE (Proteobase profiling)