Metabolomics Research Group

Group Director

Kazuki Saito

Ph.D.

Kazuki Saito

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ResearcherID

1981
Research Associate, Medical School, Keio University
1982
Ph.D., Biochemistry/Bioorganic Chemistry, University of Tokyo
1985
Research Associate, Faculty of Pharmaceutical Sciences, Chiba University
1987
Post-doctoral Fellow, Ghent University, Belgium
1990
Lecturer, Faculty of Pharmaceutical Sciences, Chiba University
1993
Associate Professor, Faculty of Pharmaceutical Sciences, Chiba University
1995
Professor, Faculty of Pharmaceutical Sciences/Graduate School of Pharmaceutical Sciences, Chiba University (-Current)
2005
Group Director, Metabolomic Function Research Group, RIKEN Plant Science Center
2010
Deputy Director, RIKEN Plant Science Center
2013
Deputy Director, RIKEN Center for Sustainable Resource Science (-Current)
2013
Group Director, Metabolomic Research Group, RIKEN Center for Sustainable Resource Science (-Current)

Contact

kazuki.saito

Metabolomics Research Group,
RIKEN Center for Sustainable Resource Science

#C714 7F Central Research Building,
1-7-22 Suehiro, Tsurumi, Yokohama, Kanagawa 230-0045 Japan
FAX: +81-(0)45-503-9489
Access to Yokohama

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Outline

Metabolomics Research Group
Metabolomics involves in the identification and quantification of all metabolites in a cell, and correlating these to genomic functions. Metabolome in the plant kingdom is extremely diverse chemically, with estimates indicating as many as 200,000 different types of chemical substances. The various compounds produced by plants are important for the existence of the plant itself, and also play a vital role in our lives as food, industrial materials, energy and medicines. Our group performs high-throughput metabolomics analyses by high-performance mass spectrometry. These non-targeted metabolomic analyses are applied to the identification of unknown gene functions and elucidation of metabolic networks. We are investigating the basic principles behind the wide variety of plant production functions, using Arabidopsis as a model. We are also elucidating the production systems for specialized plant products in crops, medicinal plants and other useful plants at a genome level, regarded as Phytochemical Genomics. Another important aspect of our research is the application of the basic findings from these results to development of sustainable resources.

Subjects

  1. Development of precision, high-throughput analytical techniques using mass spectrometry for plant metabolomics
  2. Database construction for metabolite identification and bioinformatics for metabolomic data analysis
  3. Metabolomic analysis accompanying cell and functional differentiation, stress responses, and linking to genes’ function in Arabidopsis, rice, tomato, soybeans and other crops
  4. Integrated –omics study for identification of new genes and networks involved in the biosynthesis and accumulation of flavonoids, terpenoids, alkaloids, sulfur-containing metabolites, lipids, sugars and other substances in non-model plants, and their application to the production of useful substance
Mass spectrometers using for metabolomic analysis
Co-expression gene network of plant secondary metabolism