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Chemical Genomics Research Group

Main Research Fields :
Biology
Related Research Fields :
Chemistry
Keywords :
Chemical Biology / Epigenetics / Mode of Action / Transcriptional Regulation / Chemical Screening for Drug Discovery
Project :
Advanced Research and Technology Platforms
TP

Exploiting methodologies to resolve environmental and resource-related problems using chemical biology

Group Director

Minoru Yoshida D.Agr.

Minoru Yoshida

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1986
Ph.D., University of Tokyo
1986
Assistant Professor, University of Tokyo
1995
Associate Professor, University of Tokyo
2002
Chief Scientist, Chemical Genetics Laboratory, RIKEN
2002
Visiting Professor, University of Tokyo (-current)
2003
Visiting Professor, Saitama University (-current)
2008
Group Director, Chemical Genomics Research Group, RIKEN
2011
Visiting Professor, Kyoto University (-current)
2013
Group Director, Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science (-current)
2013
Division Director, Drug Discovery Platforms Cooperation Division, RIKEN Center for Sustainable Resource Science (-current)
2013
Unit Leader, Seed Compounds Exploratory Unit for Drug Discovery Platform, RIKEN Center for Sustainable Resource Science
2018
Unit Leader, Drug Discovery Seed Compounds Exploratory Unit, RIKEN Center for Sustainable Resource Science (-current)
2020
Deputy Director, RIKEN Center for Sustainable Resource Science

CONTACT

RIKEN Center for Sustainable Resource Science
Chemical Genomics Research Group

yoshidam

WakoAccess
2-1 Hirosawa, Wako, Saitama 351-0198 Japan

Related Links

Laboratory on RIKEN Website
Chemical Genomics Research Group | RIKEN

Outline

Chemical Genomics Research Group
Identification of novel small molecular ligands is essential to understand diverse biological phenomena and to control the biological systems by chemical methods. This project focuses on the development of useful molecular ligands that are expected to contribute to an advance in environmental and resource sciences by employing chemical libraries that consist of microbial metabolites and/or synthetic compounds. In particular, we search into novel active compounds by constructing a variety of phenotypic screening systems using genetically modified animal, plant and yeast cells, and in vitro screening systems using various target proteins that include enzymes for metabolism and epigenetics. In addition, we construct new platforms for developing high throughput screening systems. Our goal is to identify and provide unique molecular ligands that are useful for chemical biology research that aims to exploit new areas of environmental and resource sciences.

Subjects

  1. Development of screening systems for bioactive compounds that target protein-protein interactions
  2. Development of comprehensive methodologies for target identification of bioactive compounds
  3. Chemical regulation of epigenetics by controlling protein methylation, acetylation, and acylation
  4. Chemical regulation of metabolism for effective bioenergy production
Live imaging of histone acetylation using Histac-K12, a fluorescent probe for visualizing histone H4K12 acetylation in living cells
Dynamic change in the histone acetylation level in response to a histone deacetylase inhibitor was visualized by using Histac-K12 in living cells and displayed as pseudocolored images. Histac-K12 enables researchers to not only analyze spatial and temporal dynamics of the histone H4K12 acetylation in living cells, but also to evaluate and screen for small molecules that modulate histone acetylation.