Chemical Genomics Research Group

Group Director

Minoru Yoshida

D.Agr.

Minoru Yoshida

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1986
Ph.D., University of Tokyo
1986
Assistant Professor, University of Tokyo
1995
Associate Professor, University of Tokyo
2002
Chief Scientist, Chemical Genetics Laboratory, RIKEN (-current)
2002
Visiting Professor, University of Tokyo (-current)
2003
Visiting Professor, Saitama University (-current)
2008
Group Director, Chemical Genomics Research Group, RIKEN
2011
Visiting Professor, Kyoto University (-current)
2013
Group Director, Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science (-current)
2013
Division Director, Drug Discovery Platforms Cooperation Division, RIKEN Center for Sustainable Resource Science (-current)
2013
Unit Leader, Seed Compounds Exploratory Unit for Drug Discovery Platform, RIKEN Center for Sustainable Resource Science (-current)

Contact

yoshidam

Chemical Genomics Research Group,
RIKEN Center for Sustainable Resource Science

2-1 Hirosawa, Wako, Saitama 351-0198 Japan
TEL: +81-(0)48-467-9516
FAX: +81-(0)48-462-4676
Access to Wako

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Outline

Chemical Genomics Research Group
Identification of novel small molecular ligands is essential to understand diverse biological phenomena and to control the biological systems by chemical methods. This project focuses on the development of useful molecular ligands that are expected to contribute to an advance in environmental and resource sciences by employing chemical libraries that consist of microbial metabolites and/or synthetic compounds. In particular, we search into novel active compounds by constructing a variety of phenotypic screening systems using genetically modified animal, plant and yeast cells, and in vitro screening systems using various target proteins that include enzymes for metabolism and epigenetics. In addition, we construct new platforms for developing high throughput screening systems. Our goal is to identify and provide unique molecular ligands that are useful for chemical biology research aiming at exploiting new area of environmental and resource sciences.

Subjects

  1. Basic and applied studies on development of drug screening systems for controling nitrogen metabolism
  2. Development of screening systems for inhibitors of energy metabolism and epigenetics
  3. Chemical biology for establishment of platforms for advanced high throughput screening systems
Live imaging of histone acetylation using Histac-K12, a fluorescent probe for visualizing histone H4K12 acetylation in living cells
Dynamic change in the histone acetylation level in response to a histone deacetylase inhibitor was visualized by using Histac-K12 in living cells and displayed as pseudocolored images. Histac-K12 enables researchers to not only analyze spatial and temporal dynamics of the histone H4K12 acetylation in living cells, but also to evaluate and screen for small molecules that modulate histone acetylation.