Molecular Ligand Target Research Team

Team Leader

Charles M. Boone

Ph.D.

Charles M. Boone

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1989
Ph.D., McGill University, Canada
1993
Assistant Professor, Simon Fraser University, Canada
1997
Assistant Professor, Queen's University, Canada
2000
Associate Professor, University of Toronto, Canada
2003
Professor, University of Toronto, Canada
2008
Senior Visiting Scientist, RIKEN
2009
Team Leader, Molecular Ligand Target Research Team, RIKEN
2013
Team Leader, Molecular Ligand Target Research Team, RIKEN Center for Sustainable Resource Science (-current)

Contact

charlieboone

Molecular Ligand Target Research Team,
Chemical Biology Research Group,
RIKEN Center for Sustainable Resource Science

#N202 Sustainable Resource Science Building,
2-1 Hirosawa, Wako, Saitama 351-0198 Japan
Access to Wako

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Outline

Molecular Ligand Target Research Team
Small molecular ligands with unique activities must have the specific target molecules that exist in their cells or organisms. Identification of the target molecules is critical for elucidating the mode of action of the molecular ligands and for drug development. However, drug target identification has been difficult in general, because the mode of interactions between the molecular ligands and their targets is not uniform. Our team aims at developing innovative techniques based on global analysis of yeast genetic interaction, which leads to quick and accurate detection of the ligand-target interactions.

Subjects

  1. Global analysis of genetic interaction between molecular ligands and their target molecules
  2. Mode of action of bioactive compounds
A microarray-based method for identification of drug targets using the fission yeast ORFeome
We created a novel strain collection in a drug-sensitive genetic background that expresses the entire fission yeast ORFeome. We can now pool this library and grow the yeast in the presence of a drug. The abundance of each strain is assessed using DNA microarray to generate a genome-wide profile of drug-gene interactions. This chemical genomics approach can rapidly determine genes involved in pathways targeted by small molecules.