Natural Product Biosynthesis Research Unit

Unit Leader

Shunji Takahashi

D.Sci.

Shunji Takahashi

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1997
D.Sci., Chiba University
1997
Postdoctoral Scholar, University of Tokyo
1998
Research Associate, Graduate School of Medicine, Chiba University
2002
Postdoctoral Scholar, University of Kentucky, USA
2005
Postdoctoral Researcher, Antibiotics Laboratory, RIKEN
2007
Senior Research Scientist, Antibiotics Laboratory, RIKEN
2011
Team Head, Cheminformatics and Compound Creation Team
2013
Unit Leader, Natural Product Biosynthesis Research Unit, RIKEN Center for Sustainable Resource Science (-current)

Contact

shunjitaka

Natural Product Biosynthesis Research Unit,
Chemical Biology Research Group,
RIKEN Center for Sustainable Resource Science

#403 Chemical Biology Building,
2-1 Hirosawa, Wako, Saitama 351-0198 Japan
TEL: +81-(0)48-467-4044
FAX: +81-(0)43-462-1353
Access to Wako

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Outline

Natural Product Biosynthesis Research Unit
Microorganism such as actinomycetes and filamentous fungi is a rich repository of valuable secondary metabolite. The understanding of biosynthetic mechanism is important to utilize microbial metabolites efficiently. Therefore we elucidate a key reaction of biosynthetic pathway by genetic and biochemical methods. We diversify microbial metabolites by modifying gene cluster and pathway engineering. In addition to the utilization of transcriptional regulators, we develop novel methods of activating biosynthetic gene cluster by small molecules, and create natural products. We construct microbial biosynthetic platform and efficiently produce valuable natural products using genetic resources from nature.

Subjects

  1. Elucidation of biosynthetic mechanism of microbial secondary metabolite
  2. Production of natural products by gene activation
  3. Construction of biosynthetic platform and creation of valuable compounds
From genetic resources to chemical resources
Identification of biosynthetic gene clusters of valuable microbial metabolites