Mechanism of forming the nine-fold centriole structure
September 13, 2022
A new mechanism to determine the shape of centrioles essential to form cytoskeleton structures
A research group at Hosei University, in collaboration with researchers at Paul Scherrer Institute (Switzerland) and the RIKEN CSRS, discovered a new mechanism for forming centrioles, the core structure of centrosomes. The centriole has a nonagonal structure made of nine protein filaments, whose shape has an essential role as the cast of the cilia. Previous studies revealed that the coordination of the cartwheel-like skeletal structure and another unknown mechanism determines the centriole’s shape. Using a single-cell model organism, Chlamydomonas, the collaborative research group revealed that the protein Bld10p/Cep135 links between microtubules to play a crucial role different from that of the cartwheel. These findings have provided new insights into the mechanism of microtubule assembly, which had been unknown previously.
- Original article
- The EMBO Journal doi:10.15252/embj.2020104582
- A. Noga, M. Horii, Y. Goto, K. Toyooka, T. Ishikawa, M. Hirono,
- "Bld10p/Cep135 determines the number of triplets in the centriole independently of the cartwheel".
- Kiminori Toyooka
Senior Technical Scientist
Mass Spectrometry and Microscopy Unit