Discovery of a new mechanism regulating transcription by lysine long-chain fatty acylation

Apr 17, 2023

Expectations for developing new cancer therapies targeting TEAD transcription factors

TEAD transcription factors, which work under the Hippo signaling pathway, are known to play significant roles in organ development while leading to cancer initiation and growth when activated aberrantly. Therefore, TEADs are now attracting attention as possible molecular targets for cancer treatment.

A joint research group from the Tokyo University of Pharmacy and Life Sciences, the RIKEN CSRS, and Nihon University discovered lysine long-chain fatty acylation as a novel posttranslational modification of TEADs. It also elucidated that this modification plays an essential role in the transcriptional activity of TEADs. This study revealed the mechanism that regulates transcription by lysine long-chain fatty acylation ahead of other countries. The findings are expected to be applied to cancer therapy targeting TEADs.

Original article
Cell Reports doi:10.1016/j.celrep.2023.112388
K. Noritsugu, T. Suzuki, K. Dodo, K. Ohgane, Y. Ichikawa, K. Koike, S. Morita, T. Umehara, K. Ogawa, M. Sodeoka, N. Dohmae, M. Yoshida, A. Ito,
"Lysine long-chain fatty acylation regulates the TEAD transcription factor".
Akihiro Ito; Senior Visiting Scientist
Minoru Yoshida; Group Director
Chemical Genomics Research Group