Identifying the fate regulator of cell differentiation that determines whether plant callus regenerate shoots or not: New mechanism to control plants’ organ regenerative capacity discovered

July 10, 2023

Expected to develop a new technology to improve the efficiency of crop tissue culture

Researchers at Nara Institute of Science and Technology and Niigata University, together with those at the RIKEN CSRS, Tokyo Medical and Dental University, and Chubu University, found a new approach to dramatically improve the efficiency of shoot regeneration from pluripotent callus cells that can be differentiated into cells of various organs. They identified a factor (protein) that determines the fate of cell differentiation by controlling plants’ organ regenerative capacity. By regulating this factor, they also developed a highly efficient way to produce a new shoot. Applying the findings of this study to agricultural crops would improve the efficiency of tissue culture technologies that are essential for genetic engineering, thus contributing to the stable food supply.

Original article
Science Advances doi: 10.1126/sciadv.adg6983
N. Ogura, Y. Sasagawa, T. Ito, T. Tameshige, S. Kawai, M. Sano, Y. Doll, A. Iwase, A. Kawamura, T Suzuki, I. Nikaido, K. Sugimoto, M. Ikeuchi,
"WUSCHEL-RELATED HOMEOBOX 13 suppresses de novo shoot regeneration via cell fate control of pluripotent callus".
Keiko Sugimoto
Team Leader
Cell Function Research Team